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Search Results for " tyrosine hydroxylase "

10

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20700	Racemetirosine	Others	Others
	Racemetirosine 是一种酪氨酸 3-单加氧酶抑制剂，因此会抑制儿茶酚胺的合成。
T7943	Fluphenazine decanoate	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Fluphenazine decanoate 是一种高度连续的多巴胺 D2受体阻滞剂，是一种长效吩噻嗪抗精神病药，用于精神分裂症的研究。
T11277	FG 7142 ZK 39106,LSU-65	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	FG 7142 (LSU-65) 是一种非选择性苯二氮卓类反向激动剂，对含 α1 亚基的 GABAA 受体具有高亲和力，Ki 为 91 nM。它还调节 GABA 诱导的 GABAA 受体上的氯离子通量，表达 α1 亚基，EC50为 137 nM。它可增加酪氨酸羟基化并导致小鼠大脑皮层中 β-肾上腺素受体的上调。
T22368	Metyrosine 甲酪氨酸,α-Methyltyrosine	COX	Immunology/Inflammation; Neuroscience
	Metyrosine (α-Methyltyrosine) 是一种选择性酪氨酸羟化酶抑制剂，可显著抑制高 COX-2 活性和有效控制血压，具有抗炎和抗溃疡作用。
T23854	Carbidine Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine	Others	Others
	Carbidine (Carbidin) 是γ-carboline 的衍生物，一种非典型的抗精神病药物。它可以在体内和体外降低DA 对伏隔核突触体释放3H-DA 和酪氨酸羟化酶活性的抑制作用。
T41274	p-Fluoro-L-phenylalanine	Hydroxylase	Metabolism
	p-Fluoro-L-phenylalanine 是酪氨酸羟化酶的一种底物。它可以与大肠杆菌的 L-亮氨酸特异性受体结合，KD 为0.26 μM。
T77549	Nurr1 agonist 2	Others	Others
	Nurr1 agonist 2 是一种 Nurr1 激动剂，EC50 值为 0.07 μM。Nurr1 agonist 2 增加 Nurr1 调节基因酪氨酸羟化酶 (TH) 和囊泡氨基酸转运蛋白 2 (VMAT2) 的 mRNA 表达。Nurr1 agonist 2 与重组 Nurr1 配体结合域 (LBD) 结合，Kd 值为 0.14 μM。Nurr1 agonist 2 可用于研究帕金森综合征。
T69569	Aquayamycin
	Aquayamycin is an anthraquinone derivative and inhibitor of the enzyme tyrosine hydroxylase..
T36207	Methylspinazarin
	Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg. \|1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gate...
T36384	DL-Tyrosine-13C9,15N L-Tyrosine-13C9,15N
	L-Tyrosine-13C9,15N is intended for use as an internal standard for the quantification of L-tyrosine by GC- or LC-MS. L-Tyrosine is a non-essential amino acid.1It is produced by hydroxylation of phenylalanine by phenylalanine hydroxylase but can also be obtained from dietary sources or degradation of endogenous proteins, resulting in L-tyrosine release.1,2L-Tyrosine is a precursor in the biosynthesis of catecholamine neurotransmitters, melanins, and thyroid hormones.3Plasma, skeletal muscle, and...

化合物

Cat.No: T20700

Target: Others

Fluphenazine decanoate

Cat.No: T7943

Target: Dopamine Receptor

Cat.No: T11277

Synonym: ZK 39106,LSU-65

Target: GABA Receptor

Cat.No: T22368

Synonym: 甲酪氨酸,α-Methyltyrosine

Target: COX

Cat.No: T23854

Synonym: Carbidine dihydrochloride,Karbidin,Carbidin,Karbidine

Target: Others

p-Fluoro-L-phenylalanine

Cat.No: T41274

Target: Hydroxylase

Nurr1 agonist 2

Cat.No: T77549

Target: Others

Cat.No: T69569

Methylspinazarin

Cat.No: T36207

DL-Tyrosine-13C9,15N

Cat.No: T36384

Synonym: L-Tyrosine-13C9,15N

Cat. No.	Product Name	Target	Signaling Pathways
T5568	H-Tyr(3-I)-OH 3-碘-L-酪氨酸,3-Iodo-L-tyrosine	Endogenous Metabolite	Metabolism
	H-Tyr(3-I)-OH (3-Iodo-L-tyrosine) 是酪氨酸羟化酶抑制剂和甲状腺激素的中间体。
T4781	N-Acetyl-L-phenylalanine N-Ac-Phenylalanine,N-乙酰-L-苯丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	N-Acetyl-L-phenylalanine (N-Ac-Phenylalanine) 是一种大肠杆菌中的主要酰基氨基酸，由 L-苯丙氨酸和乙酰辅酶 A 合成。
T5290	(S)-2-Hydroxy-3-phenylpropanoic acid L-(−)-3-Phenyllactic acid,L-3-苯乳酸	Others; Endogenous Metabolite	Metabolism; Others
	(S)-2-Hydroxy-3-phenylpropanoic acid (L-(−)-3-Phenyllactic acid) 是苯丙氨酸的代谢产物。苯丙酮尿症患者体液中苯丙氨酸的水平升高。
TN3607	Catalpalactone	cAMP	GPCR/G Protein
	Catalpalactone exhibits high antitermitic, and cytotoxic activities, it exhibits potent inhibitory effects on lipopolysaccharide-induced NO synthesis in RAW 264.7 cells , with IC50 values of 9.80 microM. Catalpalactone can inhibit dopamine biosynthesis by

天然产物

Cat.No: T5568

Synonym: 3-碘-L-酪氨酸,3-Iodo-L-tyrosine

Target: Endogenous Metabolite

N-Acetyl-L-phenylalanine

Cat.No: T4781

Synonym: N-Ac-Phenylalanine,N-乙酰-L-苯丙氨酸

Target: Others, Endogenous Metabolite

(S)-2-Hydroxy-3-phenylpropanoic acid

Cat.No: T5290

Synonym: L-(−)-3-Phenyllactic acid,L-3-苯乳酸

Target: Others, Endogenous Metabolite

Cat.No: TN3607

Target: cAMP

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